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KMID : 0061119810090000060
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Bulletin of the Clinical Research Institute
1981 Volume.9 No. 0 p.60 ~ p.60
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Effect of Various Maximization Agents on Photoallergic contact Dermatitis in Guinea Pigs
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Lee Youn-Bok
Houg Won
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Abstract
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Maximization test was designed to detect the least sensitization potential of haptens. There are several advocated maximization agents such as ultraviolet ray, sodium lauryl sulfate, Freund´s complete adjuvant, etc.
The present experiment was conducted to assess the comparative effects of of these maximization agents on the induction of photoallergic contact dermatitis in guinea pigs.
Musk ambrette was employed as a sensitizer of photoallergic contact dermatitis. Harber´s procedure was grossly applied for its induction. For the elicitation, Kim and Houh´s method was applied, reversing the order of three different concentrations of photosensitizers advocated by Harber´s method, with the lowest concentration applied to a site closer to the nuchal region.
The most effective maximization agent observed was Freund´s complete adjuvant, followed by sodium lauryl sulfate. UVB was found to be the least effective in this respect. The reaction of Freund´s complete adjuvant group was in good accord with the experimental result shown by Harber et al However, stronger reaction occurred in the area closer to the nuchal region in spite of the application of a lower concentration and weaker reaction was shown in the area closer to the sacral region with higher concentration. From this experiment it may be inferred that the closer the area to the nuchal region the stronger the reaction occurred regardless of the concentration of a sensitizing agent.
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KEYWORD
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